Because the downstream of many inflammatory pathways and the upstream of cell proliferation or extracellular matrix-related pathways is the PI3K-Akt pathway, and the inhibit of this pathway was reported that reduce inflammatory response (Shan et al., 2021), intimal hyperplasia tumor cell proliferation (Stark et al., 2015; Zhang et al., 2020). This evidence concerns the gene AKT1 and neoplasm.