VEGFA and chronic obstructive pulmonary disease: Also, left ventricular fractional area change, fractional shortening, stroke volume, and left ventricular mass did not change 6 days after Ad-VEGF-B186R127S and Ad-VEGF-B186 gene transfers as compared to controls which showed impairment of the heart functions (Figures 9B–D) and no cardiac arrhythmias were detected in the study groups (Supplementary Figure S7).