For example, an evaluation of KISS1R, SEPT9, and CSAD methylation in bladder cancer improved the AUC for predicting lymph node status (AUC = 0.68–0.72), compared with KISS1R (AUC = 0.67) SEPT9 (AUC = 0.58), or CSAD (AUC = 0.70) alone (42). The gene discussed is KISS1R; the disease is urinary bladder carcinoma.