In NPC models, c-Abl signaling leads to increased p73 pro-apoptotic protein levels (Klein et al., 2011), amyloid precursor protein (APP) amyloidogenic processing (Yáñez et al., 2016), increases in histone deacetylase 2 (HDAC2) levels, repression of neuronal and synaptic genes, and retention of TFEB in the cytoplasm (Gonzalez-Zuñiga et al., 2014). The gene discussed is HDAC2; the disease is nasopharyngeal carcinoma.