Therefore, if the present model were correct, then inhibition of NOTCH signaling in severe, COVID-19 that is unresponsive to other therapies might (a) decrease furin expression, decrease NOTCH expression, increase ADAM17 expression, and thus decrease new avenues of SARS-CoV-2 infection; (b) decrease inflammation by inhibiting NOTCH : IL-6 positive feedback loop; and (c) favor regeneration of alveoli and healing of respiratory apparatus. The gene discussed is IL6; the disease is COVID-19.