Given the described importance of LRV1 in the leishmaniasis outcome, progression, relapse, and treatment failure, hub genes associated to the presence of LRV1 are of utmost interest when designing strategies to fight leishmaniasis (Hartley et al., 2014; Adaui et al., 2016; Bourreau et al., 2016; Rossi et al., 2017). Several relevant transducers and transcription factors were present in the 8h_coral3 and 8h_bisque4 modules in WT analysis (e.g., Myd88, Keap1, Tank, Ikbke, Stat1, Stat2, Irf1, Irf5, Irf7, Ets2, and Xbp1). Here, IRF5 is linked to leishmaniasis.