SCRIB and eye neoplasm: For instance, it has been demonstrated that deletion of scribble/scrib (the ortholog of human scribble planar cell polarity protein, SCRIB) in Drosophila melanogaster (scrib KO flies), a well-known model of eye tumor that invades the central nervous system, reduces lipid droplet content in the adipose tissue and increases muscle atrophy measured by micro-computerized tomography, as well as increases LC3 processing in all the aforementioned tissues, suggesting that scrib-deficient tumor cells obtain nutrients by wasting host organs (88).