PTEN and neoplasm: Most importantly, tamoxifen-induced double knock-out mice for transforming growth factor β1 receptor, TGFBR1, and phosphatase and tensin homolog, PTEN, display a reduction in tumor growth, as well as a weak immunohistochemical staining for MTOR phosphorylation at Ser-2448 and SQSTM1/p62, after exposure with 5 mg/kg sepantronium bromide (93).