In patients with depression under stress, an excessive corticotropin-releasing hormone (CRH) level leads to the inhibition of the HPG axis, and increased cortisol level further inhibits the action of GnRH neurons, luteinizing hormone (LH) amplitude, follicle-stimulating hormone (FSH) levels, and LH pulse frequency (11–13). Here, PLOD1 is linked to depressive symptom measurement.