Although it is unknown if the timing of the preovulatory surge in women involves projections from the SCN to the GnRH neuronal network and POA kisspeptin neurons, it is tempting to speculate that elevated testosterone might have an impact on the output of the central circadian clock in PCOS patients similar to what we observed in adult PNA female mice. The gene discussed is GNRH1; the disease is polycystic ovary syndrome.