The entry of SARS-CoV-2 in the host cell through ACE2 activates the STAT3/NF-kB pathway leading to the production of proinflammatory cytokines and chemokines that can cause a severe systemic hyperinflammation known as “cytokine storm”, responsible for acute respiratory distress syndrome (ARDS) and multi-organ failure (8). This evidence concerns the gene NFKB1 and acute respiratory distress syndrome.