MAPK3 and Wilson disease: By analyzing the gonadotropin-releasing hormone (GnRH), follicle-stimulatin hormone FSH, luteinizing hormone (LH), testosterone (T) content, fertility, apoptosis-related proteins in hypothalamus, and the pituitary tissues and expression levels of extracellular signal-regulated kinase (ERK)1/2 and P-ERK1/2 proteins, the mechanism of male fertility decline in the TX mouse model of WD was studied, providing an objective theoretical basis for clinical male WD complicated with reproductive system function impairment.