By analyzing the gonadotropin-releasing hormone (GnRH), follicle-stimulatin hormone FSH, luteinizing hormone (LH), testosterone (T) content, fertility, apoptosis-related proteins in hypothalamus, and the pituitary tissues and expression levels of extracellular signal-regulated kinase (ERK)1/2 and P-ERK1/2 proteins, the mechanism of male fertility decline in the TX mouse model of WD was studied, providing an objective theoretical basis for clinical male WD complicated with reproductive system function impairment. Here, BRD2 is linked to Wilson disease.