AKT1 and polycystic ovary syndrome: In the present study, we observed increased CYP17A1 gene expression and activation of the PI3K/AKT/mTOR signaling pathway and that multiple cystic follicles appear in the PCOS group; after DOP and MET treatment, CYP17A1 and PI3K/AKT/mTOR pathway were downregulated, and the morphology of the polycystic ovary was improved.