In those molecularly selected patients harboring RET fusions, RET mutations, or Neurotrophic tyrosine receptor kinase (NTRK) fusions, treatment with pralsetinib and selpercatinib (RET inhibitors, which are Food and Drug Administration (FDA)-approved options for advanced progressive MTC) or entrectinib and larotrectinib (NTRK inhibitors) must be considered (8). The gene discussed is RET; the disease is medullary thyroid gland carcinoma.