Besides, in the whole sample of hypogonadal men with adult-onset FSH elevation, LS BMD was directly associated with both age at diagnosis (r=0.360, p=0.002) and overweight/obesity prevalence (r=0.338, p=0.003), but not with smoking habits, cfT and 25OHD levels, whilst FN BMD tended to be associated with age at diagnosis (r=0.320, p=0.06) but not with overweight/obesity prevalence, smoking habits, cfT and 25OHD levels. The gene discussed is BRD2; the disease is obesity due to melanocortin 4 receptor deficiency.