In addition, the OR was attenuated after further adjustment for hypertension, history of stroke, SBP, HbA1c, HDL-C, insulin or metformin usage and serum tHcy, in which the highest tertile of TyG index levels compared with the lowest had an OR of 1.933 (95% CI: 1.010 to 3.698; P for trend = 0.047) (Table 4). This evidence concerns the gene INS and Stroke.