INS and Stroke: In multivariate binary logistic regression analysis, the association remained significant (OR: 2.241; 95% CI: 1.439 to 3.490; P <0.001), after adjusting for age, education, SBP, history of stroke, HbA1c, HDL-C, serum tHcy, insulin or metformin usage and severe CSVD burden (Table 2).