In the fully adjusted models which included age, sex, HIV-status, fat mass and fat free mass and CRP, a change of 5 kj/kg/day of PAEE was associated with reduced risk of pre-diabetes (RRR=0.98, 95%CI: 0.96, 0.99) and diabetes (RRR=0.92, 95%CI: 0.88, 0.96) while an increment of 5 beats/min of SHR was associated higher risk of diabetes (RRR=1.06, 95%CI: 1.01, 1.11) (Table 5). The gene discussed is CRP; the disease is diabetes mellitus.