In accordance with the present findings, we have recently reviewed the potential role of phytosterols particularly β-sitosterol and its perspectives on the translocation of GLUT4 containing vesicles on the PM, which is crucial for the glucose uptake and oxidation in insulin-sensitive tissues such as skeletal muscle, adipose tissue, and in reducing the diabetes risk and/or insulin resistance [69]. The gene discussed is SLC2A4; the disease is Insulin resistance.