TP53 and non-small cell lung carcinoma: TP53 and CSMD3 were the two most frequently mutated genes in NSCLC (Liu et al., 2012), and their mutation status was closely associated with high TMB causing genomic instability and poor clinical prognosis (Zhang et al., 2017; Bernard et al., 2020; Lu et al., 2021; Wen et al., 2021).