BCL2 and neoplasm: It is well known that a decreased Bax/Bcl-2 ratio indicated that apoptosis was inhibited, and MMP9 was an important enzyme that degraded the extracellular matrix (ECM) during tumor metastasis and was highly associated with tumor invasion (Ha et al., 2019; Buttacavoli et al., 2021; Idiiatullina et al., 2021).