For example, chemokine ligand CCL2 and CXCL1 were both genes related to IL-17 pathway, CCL2 promoted cancer cell migration and recruited immunosuppressive cells to the tumor microenvironment, favoring cancer development (Xu et al., 2021), CXCL1 was associated with immunosuppression and tumorigenesis in various tumor types, blocking CXCL1 in mice can suppress CAC progression (Liu et al., 2019). This evidence concerns the gene CCL2 and neoplasm.