CFTR and cystic fibrosis: Ivacaftor/tezacaftor/elexacaftor (Kaftrio)aKaftrio is indicated in a combination regimen with ivacaftor for the treatment of cystic fibrosis (CF) in patients aged 6 years and older who have at least one F508del mutation in the cystic fibrosis transmembrane conductance regulator (CFTR) gene