The pathways are mainly involved with cancer or malignant tumor (colorectal cancer, pancreatic cancer, pathways in cancer, melanoma, chronic myeloid leukemia, small cell lung cancer, and prostate cancer) and cellular signaling and developments (regulation of actin cytoskeleton, TGF-beta signaling pathway, focal adhesion, p53 signaling pathway, adherens junction, gap junction, MAPK signaling pathway, cell cycle, cell adhesion molecules (CAMs), and Wnt signaling pathway) (Figure 2). This evidence concerns the gene TP53 and Familial prostate cancer.