CTHRC1 and metastatic neoplasm: Furthermore, we investigated the expression level of CTHRC1, FBN2, NTM, PDGFC, PDLIM3, and SLC16A3 among the normal, primary tumor, and metastatic tumors in a colonic fibroblast dataset and revealed that these genes are gradually deregulated among the three groups, indicating their roles in tumor progression (Welch’s t-test, p < 0.05) (Figure 7).