Since the upregulated group of CTHRC1, NTM, PDGFC, PDLIM3, and SLC16A3 and the downregulated group of FBN2 genes are consistently correlated with the shorter survival time in TCGA and GEO datasets, we investigated the association of these genes with immune score and stromal scores in colon cancer. Here, CTHRC1 is linked to malignant colon neoplasm.