Our analysis revealed that the upregulated group of CAFs-derived upregulated genes included CTHRC1, EMB, FOXS1, LYPD1, NTM, PDGFC, PDLIM3, SLC16A3, SYNPO2L, and TNFSF4 (Figure 4A) and the lower expression group of downregulated genes included ABCA5, FBN2, IMPA2, and TIMP4 (Figure 4B) are significantly correlated with shorter survival time of colon cancer patients (Figure 4). Here, LYPD1 is linked to colonic neoplasm.