After the brainstem glioma excision, dura mater reparation, and cranioplasty, the patient was diagnosed with astrocytoma, IDH-mutant WHO grade II based on histopathology and molecular analysis which showed mutations in IDH1 and TP53, CDK4 amplification, BRCA2, and chromosomal deletion (21q11.2-q22.3,1q23.3-q44) using the targeted 131 + 4 panel. This evidence concerns the gene IDH2 and astrocytoma (excluding glioblastoma).