One study from the US reported that ferritin could distinguish significant fibrosis (F2–F4), advanced fibrosis (F3–F4) and cirrhosis (F4) from less severe fibrosis; the associations remained significant when age, gender and race were adjusted, yet became non-significant when more variables were included, e.g., BMI, medical history of diabetes, waist circumference, laboratory analysis results including alanine aminotransferase (ALT), etc. (53). This evidence concerns the gene GPT and Cirrhosis.