POU5F1 and hyperthyroidism: In the present study, we identified 44 novel variants in 10 loci associated with hyperthyroidism, including CTLA4, HCP5, HLA-B, POU5F1, CCHCR1, HLA-DRA, HLA-DRB9, TSHR, RPL17P3, and CEP128. To consider differences in racial backgrounds, and proved that these SNPs is really significant associate with the disease.