In this study, we explored the functionality and feasibility of two MDR-based programs, Cox-MDR (Lee et al., 2012) and GMDR 0.9 (Lou et al., 2007) and applied them to examine single-locus and multi-loci interactions in MMP family and VEGF interaction network genes in relation to survival outcome risks in colorectal cancer. Here, VEGFA is linked to colorectal cancer.