MMP2 and metastatic neoplasm: As mentioned above, MMP2 has been shown to be overexpressed in colorectal cancer tumors compared to normal tissues (Dong et al., 2011; Gao et al., 2016), and is associated with metastatic tumor phenotype (Dong et al., 2011; Gao et al., 2016) and shorter survival times in colorectal cancer (Dong et al., 2011).