This prognostic model consists of eight MRGs, namely OPTN, ATG12, CSNK2A2, MFN1, PGAM5, SQSTM1, TOMM22, and TOMM5. Existing studies have shown that ATG12 promotes HCC by participating in a variety of long non-coding RNAs (Li et al., 2019; Wei et al., 2019), and MFN1 reduces oxygen consumption and ATP production in HCC cells by promoting mitochondrial fusion (Li et al., 2020). Here, TOMM22 is linked to hepatocellular carcinoma.