This prognostic model consists of eight MRGs, namely OPTN, ATG12, CSNK2A2, MFN1, PGAM5, SQSTM1, TOMM22, and TOMM5. Existing studies have shown that ATG12 promotes HCC by participating in a variety of long non-coding RNAs (Li et al., 2019; Wei et al., 2019), and MFN1 reduces oxygen consumption and ATP production in HCC cells by promoting mitochondrial fusion (Li et al., 2020). This evidence concerns the gene ATG12 and hepatocellular carcinoma.