The DENRGs were particularly involved in necroptosis, lipids and atherosclerosis, TNF signaling pathway, legionellosis, cytosolic DNA-sensing pathway, RIPK1-mediated regulated necrosis, TRAIL signaling, Kaposi sarcoma-associated herpesvirus infection, and the NLRP3 inflammasome (Figure 4B and Table 3). The gene discussed is NLRP3; the disease is atherosclerosis.