Intriguingly, Chemotherapy can activate endoplasmic reticulum stress to produce ICD by regulating the expression of intracellular XBP1 in multiple cancers (eg., melanoma, colorectal carcinoma, and acute myeloid leukemia) (Schardt et al., 2009; Pozzi et al., 2016; Prieto et al., 2019). This evidence concerns the gene XBP1 and cancer.