In addition, KEGG analysis showed that the enriched KEGG pathways in patients with low-risk colon cancer compared with the high-risk group were cytokine–cytokine receptor interaction, cell cycle, chemokine signaling pathway, NK cell-mediated cytotoxicity, and TNF signaling pathway (Figure 5B and Supplemental Table S8). This evidence concerns the gene TNF and malignant colon neoplasm.