C5orf46 and digestive system neoplasm: Several reports implicate C5ORF46 as having a pro-tumoral role with possible prognostic value in the development of pancreatic adenocarcinoma (PAAD) (Makler and Narayanan, 2017), colon adenocarcinoma (COAD) (Chen et al., 2021) and stomach adenocarcinoma (STAD) (Cheng et al., 2020), which underline the value of studying C5ORF46 in GI tumors (Makler and Narayanan, 2017; Cheng et al., 2020).