Of the five GI tumors with statistical significance between C5ORF46 expression and disease stage, in all cases, stage II presented a higher C5ORF46 expression level compared with stage I. COAD (p = 0.033) and ESCA (p = 0.011) demonstrated differential C5ORF46 expression between stages I and III. The gene discussed is C5orf46; the disease is digestive system neoplasm.