C5orf46 and digestive system neoplasm: Figures 9A,B demonstrate that C5ORF46 expression significantly and positively correlated with genes encoding chemokine and chemokine receptors, especially in COAD and READ. The results show that the majority of significant correlations between C5ORF46 expression and immune-related genes in GI tumors were positive, suggesting that C5ORF46 may play a role in modulating the pattern of tumor immunity by regulating the expression levels of the above-mentioned immune-related genes.