Genes enriched in the high C5ORF46 expression group were mainly from the interferon alpha (IFNA) family, for example IFNA4, IFNA8, IFNA6, and IFNA14, the major effector cytokines in mediating a host immune responses against viral infections (González-Navajas et al., 2012). This evidence concerns the gene IFNA8 and viral infectious disease.