The KEGG terms indicated that C5ORF46 activates several immune-related pathways in PAAD, READ and STAD, including antigen processing and presentation, cytosolic DNA-sensing signaling, regulation of autophagy, autoimmune thyroid disease pathways, and RIG-I-like receptor signaling and Toll-like receptor signaling. This evidence concerns the gene C5orf46 and pancreatic adenocarcinoma.