We found C5ORF46 expression displayed significant difference between stages I and II in five out of seven types of GI tumor, including COAD (p = 0.018; Figure 5B), ESCA (p = 0.0014; Figure 5C), LIHC (p = 0.026; Figure 5D), PAAD (p = 0.014; Figure 5E), and READ (p = 0.0031; Figure 5F). This evidence concerns the gene C5orf46 and digestive system neoplasm.