PIEZO2 and cancer: In many types of cancer, calcium influx has been proven to exert effects on cancer cell behavior including cell proliferation (Capiod, 2011), apoptosis (Orrenius et al., 2003), and cell death (Trump and Berezesky, 1995) et al. We found that Piezo2 was significantly associated with calcium ion transport and calcium signaling pathway which was consistent with its ion channel properties.