In subsequent detection of tumor cell lines, we found that Piezo2 was expressed in the kidney and urinary bladder, lung, mesenchymal, and lymphoid tumor cell et al. Through the analysis of TCGA data, the results showed that Piezo2 was up-regulated in tumor tissues from CHOL, HNSC, KIRC, LIHC, PCPG, STAD, and THCA compared with normal tissues. The gene discussed is PIEZO2; the disease is neoplasm.