The associations between Piezo1 and cancers have been extensively studied, such as colon cancer (Sun et al., 2020), breast cancer (Luo et al., 2022), and bladder cancer (Etem et al., 2018) et al., whereases the role of Piezo2 in pan-cancer has not been well studied. This evidence concerns the gene PIEZO2 and malignant colon neoplasm.