Piezo1 and Piezo2 played significant roles in regulating diverse physiological processes including sensing tactile sensations (Wang et al., 2019), regulating blood pressure (Zeng et al., 2018), prompting vascular development (Yang et al., 2016), and conducting mechanical force (Coste et al., 2010) et al. In addition to these, increasing shreds of evidence demonstrated that piezo protein could influence cancer development, progression, and invasion. This evidence concerns the gene PIEZO2 and cancer.