CAMK2B and early-onset autosomal dominant Alzheimer disease: In consequence, we performed the differential analysis of CaMK2B in two Alzheimer’s Disease RNA-sequencing (RNA-seq) datasets GSE173955 and GSE159699, and observed that CaMK2B was significantly differentially expressed in the two datasets (p < 0.0028 in GSE173955, p < 0.0425 in GSE159699, Wilcoxon ranksum test) (Figure 3D).