AMER1 and osteopathia striata with cranial sclerosis: In hemizygous males, the phenotype is typically more severe, varying from lethal to a milder survivable form.(8) Somatic mosaicism of AMER1 mutations has been reported in male patients with OSCS(8, 9, 10, 11) and in one asymptomatic mother of OSCS patients.(12) Germline mosaicism has also been reported.(13)