SMG1 and neoplasm: In B16/F10 C57/BL6 melanoma model, we initiated the treatment early following the schedule depicted in Figure 3C. Despite the aggressiveness of the B16/F10 model the antitumor response mediated by the cytotoxic effect of AS1411 aptamer was still quite strong with significant impact on tumor growth of mice treated locally with either AS1411-control AsiC or AS1411-SMG1 AsiC (Figure 3D).