Targeting inhibition of SMG1 was assessed as well in Panc02 and B16/F10 tumor cells pre-transfected with SMG1-psiCHECK reporter luciferase system, and we observed a significant reduction of luciferase signal proportional to the level of RNAi-mediated inhibition in both cell lines (Figure 2C). This evidence concerns the gene SMG1 and neoplasm.