In parallel, mice were also injected with anti-CTLA-4/PD-1 antibodies on the same schedule shown in Figure 5C. Of note, the AS1411-SMG1 AsiC and the anti-CTLA-4/PD-1 antibodies display similar antitumor effect in the 4T1 tumor model (Figure 5D). This evidence concerns the gene SMG1 and neoplasm.