SKP2 and ischemia: The ALKBH5–m6A–YTHDF1–Hippo–YAP1 pathway,54 and regulation of Hippo-mediated S-phase kinase associated protein 2 (Skp2),198 can link these associations with suppression of polyploidy, cytokinesis failure,199 and thus enhanced cardiac regeneration and cardiomyocyte proliferation after ischemia.200