Congruent with these prohypertrophic findings, Tanshinone IIA (TanIIA), an active compound from Salvia miltiorrhiza, was shown to inhibit pressure-overload-induced myocardial hypertrophy, the mechanism, as evaluated in AngII-stressed cardiomyocyte culture, of which was suggested to operate via downregulation of ALKBH5 to downregulate Galectin-3 via respective mRNA m6A methylation.141. This evidence concerns the gene AGT and cardiac hypertrophy.