elegantly unveiled a cell-specific function for an epigenetic regulator SET domain containing 2, histone lysine methyltransferase (SETD2), in hypoxic pulmonary hypertension with its VSMC-targeted knockout as a pulmonary hypertension-promoting regulator and positive upstream regulator of METTL14 in vivo.76 This evidence concerns the gene SETD2 and pulmonary arterial hypertension.