As an interesting link, JAK–STAT3 signaling has been implicated in cardiac anti-apoptosis, cell-cycle re-entry, differentiation, regeneration, fibrosis, hypertrophy, MI, HF,270,271 and in the regulation of induced pluripotency by acting through m6A-YTHDF1/YTHDF2 and suppressor of cytokine signaling 3 (SOCS3).272. This evidence concerns the gene SOCS3 and hydrops fetalis.