Moreover, YTHDF1 is upregulated alongside increased m6A contents in hypertensive pulmonary arteries, which were shown to promote hyperproliferation of human PASMCs in vitro as well as pulmonary hypertension development in vivo by increasing m6A-dependently translation of melanoma antigen gene (MAGE) family member D1 (MAGED1) mRNA, expression of subsequent protein, which finally led to upregulation of proliferating cell nuclear antigen (PCNA).80 This evidence concerns the gene YTHDF1 and pulmonary arterial hypertension.