METTL3 and cardiomyopathy: While METTL3 and ALKBH5 have been reported to be downregulated in PA-induced inflammation in human cardiomyocytes,154 METTL3 was measured to be upregulated in mice myocardium with high-fat-diet-induced cardiomyopathy,155 again highlighting methodological, cell-type-specific, and species-dependent differences.