Indeed, as discussed later in future perspectives, hypoxic metabolism in general may hamper m6A eraser function, but FTO and ALKBH5 eraser levels have also been measured to downregulate in ischemic myocardium,107,131,135 and their overexpression—as well as METTL3 knockout—has proved beneficial against the development of HF.140. This evidence concerns the gene FTO and hydrops fetalis.