For example, the post-MI cardioprotection of ALKBH5 against HF development seem to be conveyed by hypomethylation-dependent stabilization of Ythdf1 mRNA, thus upregulating YTHDF1 protein without altering its transcription.54 Moreover, recent evidence suggests most m6A to be non-functional enzymatic noise, also in myocardium.277. The gene discussed is YTHDF1; the disease is hydrops fetalis.