Based on the discovery for A-to-I editing to control diastolic blood pressure via Flna mRNA editing,116 thus producing an actin crosslinking FLNA, heavily implicated in arterial wall integrity (see also section “hypertension”),252 further investigations regarding A-to-I editing in also controlling aneurysm pathophysiology are warranted and rational. The gene discussed is FLNA; the disease is hypertensive disorder.