Taken together, the above results in our study shed new lights on novel targets such as the fact that SFN could be used to upregulate AQP4 expression, which could result in enhanced soluble protein clearance through AQP4-mediated glymphatic pathways and be of great importance in the treatment of protein misfolding diseases, such as the early stage of AD. Here, AQP4 is linked to proteostasis deficiencies.