When stimulated by allergens, the levels of CD4+ and CD8+ in the peripheral blood are obviously abnormal, in which the rise of CD4+ is late-onset asthma, and the decline of CD8+ is rapid-onset asthma.8,9 In this study, peripheral blood T lymphocyte subsets of children with bronchial asthma accompanied by recurrent infection were investigated. The gene discussed is CD4; the disease is asthma.