It is an index for predicting the prognosis of a variety of tumors in recent years.23,24 Another study has shown that the signal transduction pathway is activated and transferred from the cytoplasm to the nucleus, which plays an important role in regulating and inducing the expressions of multiple genes and anti-tumor cell apoptosis.25 In our study, the STAT3 level of the observation group was lower than that of the control group, suggesting that total thyroidectomy can improve the prognosis of the patients. The gene discussed is STAT3; the disease is neoplasm.