If the content of WBC in the body is too high, it indicates that the body causes tissue and organ infection due to bacterial invasion.18 The retrospective analysis results of this study found that the levels of serum CRP, WBC and PCT in the observation group after treatment were lower than those in the control group (P<0.05), which was consistent with the research results of LV Q et al.19, which further confirmed that the combination of Cefoperazone and tigecycline in the treatment of ICU infection can effectively control the patient’s condition and promote the good prognosis of the disease. The gene discussed is CRP; the disease is infection.