F5 and thalassemia: In Pakistan, a huge chunk of children suffers from inherited disorders like Thalassemia, hemophilia, rare bleeding disorders (deficiencies of coagulation factors as fibrinogen, Factor (F) FII, FV, FVII, combined FV/FVIII, FX, FXI, and FXIII) and Platelet function defects (Glanzmann Thrombasthenia, Bernard Soulier syndrome, Storage pool defects etc.)who require frequent transfusions as a part of their therapy.4,5