ATP5IF1 and neurodegenerative disease: The known effects of IF1 on ATP synthase dimer stability and cristae organization might be protective for neurodegenerative diseases, since during brain aging and neurodegeneration many mitochondria undergo enlargement and structural disorganization (Moreira et al., 2010) often followed by altered mitochondrial function (Bosetti et al., 2002; Schmidt et al., 2008; Rossi et al., 2020, 2021).