The TUNEL staining and western blotting results of Bax, cleaved-caspase3, caspase6, and caspase9 showed a significantly higher expression of apoptosis in WT + Dox group mice than those of the group to IKKε-KO + Dox group mice, which suggested that the IKKε knockout could inhibit apoptosis in Dox-induced DCM. Here, IKBKE is linked to familial dilated cardiomyopathy.