Previous studies showed that activation of AMPK could be beneficial in the treatment of type 2 diabetes (T2D) and insulin resistance (Merrill et al., 1997; Mu et al., 2001; Fryer et al., 2002; Foretz et al., 2005; Andreelli et al., 2006). The gene discussed is PRKAA1; the disease is type 2 diabetes mellitus.