MAPT and Cognitive impairment: A growing body of evidence suggests that an abnormal level of certain steroid hormones including testosterone (T) and cortisol (C) are correlated with the main features of AD pathogenesis, in particular β-amyloid deposition, tau hyperphosphorylation, alongside synaptic deficits and cognitive disorders, disturbance of memory, mind and mood, depression, etc. in animal models and human patients (Laske et al., 2009; Wang et al., 2018; Ouanes and Popp, 2019).