SRF and myocardial infarction: In the rat model of MI, for example, the β blocker propranolol can reduce miR-1 expression by inhibiting the beta-adrenoceptor–cAMP–protein kinase A (PKA) signaling pathway and suppressing the expression of transcriptional factor serum response factor (SRF) (149), thus the propranolol may improve MI via downregulating miR-1 then inhibiting pyroptosis in cardiomyocytes (85).