While the AngII model in Apoe−/− mice more closely mirrors the human disease in its inclusion of hypercholesterolemia, a relatively chronic disease development, and the heterogeneity of aneurysms between mice, its mortality rate reaches higher (nearly 40%) than in humans (17) and the thrombus occurs extraluminally due to medial rupture resulting in adventitial dissection (17). This evidence concerns the gene APOE and aneurysm.