The present meta-analysis aimed to elucidate the associations between GDF-15 and FGF-23 in the risk of atrial fibrillation (AF).<h4>Methods</h4>An electronic search was conducted in the Cochrane Library, PubMed, and Embase databases from inception until February 27, 2021. The gene discussed is GDF15; the disease is atrial fibrillation.