Abnormal calcium handling associated with ANKB variant expression is a plausible pathophysiological mechanism underlying the increase in frequency of delayed afterdepolarizations and susceptibility for cardiac arrhythmias observed with ANK2 cardiac variants (104, 106), as well as a possible mechanism for the increased susceptibility to epileptic seizures associated with some ANK2 variants. This evidence concerns the gene ANK2 and cardiac arrhythmia.