An earlier study by Healy et al. (114) described that mice with partial global loss of Ank2 (Ank2+/−) exhibit impaired oral glucose tolerance likely secondary to decreased expression of the inositol trisphosphate receptor in pancreatic islets, which mediates the signaling for augmented glucose-induced insulin secretion after parasympathetic stimulation (115, 116). The gene discussed is ANK2; the disease is glucose measurement.