It has been well established that lncRNAs play an important role in myocardial infarction (MI)-induced cardiac fibrosis and HF, such as lncRNA-Safe (74), LncHrt (36), Wisp2 super-enhancer-associated RNA (Wisper) (75), and cardiac fibroblast-associated transcript (Cfast) (76). The gene discussed is CCN5; the disease is myocardial infarction.