AKT1 and myocardial infarction: Besides, lncRNA small nucleolar RNA host gene 1 (Snhg1) exerts anti-apoptotic effects on cardiomyocyte and myocardial infarction (MI) heart, by activating the PI3K/AKT/c-Myc pathway, which in turn enhances the expression of Snhg1, thus forming a positive feedback loop (70).