Yin et al. (2015) showed that autophagy inhibition caused severe ER stress in adipocytes and thus induced adaptive responses to extracellular disturbances, attenuating insulin resistance deterioration (Zhou et al., 2009). Due to its ability to suppress insulin receptor signaling, ER stress has been proposed as an important factor in peripheral insulin resistance and type 2 diabetes (Ozcan et al., 2004). Here, INSR is linked to Insulin resistance.